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Article

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency

29 Dec 2005

Abstract excerpt

The homozygous deletion of the inducible costimulator (ICOS), an activation-induced member of the CD28 family on T cells, causes an antibody deficiency syndrome in affected humans. The identification of a total of 9 ICOS-deficient patients revealed that this monogenic disease comprises the full clinical phenotype described for common variable immunodeficiency (CVID), including recurrent bacterial infections,...

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PMID: 16384931
DOI: 10.1182/blood-2005-07-2955

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