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Article

A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2002

Villegas Eric N, Lieberman Linda A, Mason Nicola, Blass Sarah L, Zediak Valerie P, Peach Robert, Horan Tom, Yoshinaga Steve, Hunter Christopher A

Abstract excerpt

Long-term resistance to Toxoplasma gondii is dependent on the development of parasite-specific T cells that produce IFN-gamma. CD28 is a costimulatory molecule important for optimal activation of T cells, but CD28(-/-) mice are resistant to T. gondii, demonstrating that CD28-independent mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12097399
DOI: 10.4049/jimmunol.169.2.937

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12097399-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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