Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective effector memory CD4 T cells depend on ICOS for survival.

PloS one - 18 Feb 2011

Moore Tamson V, Clay Bryan S, Ferreira Caroline M, Williams Jesse W, Rogozinska Magdalena, Cannon Judy L, Shilling Rebecca A, Marzo Amanda L, Sperling Anne I

Abstract excerpt

Memory CD4 T cells play a vital role in protection against re-infection by pathogens as diverse as helminthes or influenza viruses. Inducible costimulator (ICOS) is highly expressed on memory CD4 T cells and has been shown to augment proliferation and survival of activated CD4 T cells. However, the role of ICOS costimulation on the development and maintenance of memory CD4 T cells remains controversial. Herein,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, T-Lymphocyte
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoprotection

Share to Immunologic Memory

Share to Inducible T-Cell Co-Stimulator Protein

Share to Influenza A virus

Share to Interleukin-4

Share to Orthomyxoviridae Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 21364749
DOI: 10.1371/journal.pone.0016529
PMCID: PMC3041765

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Protective effector memory CD4 T cells depend on ICOS for survival.PMID 21364749Read ↗

Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.Semantic proximity Read ↗

Opposing Effects of ICOS on Graft-versus-Host Disease Mediated by CD4 and CD8 T CellsSemantic proximity Read ↗

The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS InfectionSemantic proximity Read ↗

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.Semantic proximity Read ↗

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiencySemantic proximity Read ↗

Inducible costimulator-ligand (ICOS-L).Semantic proximity Read ↗

A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.Semantic proximity Read ↗

Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines.Semantic proximity Read ↗

ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.Semantic proximity Read ↗

Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen.Semantic proximity Read ↗

The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.