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Article

Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.

The Journal of experimental medicine - 20 Jan 2003

Löhning Max, Hutloff Andreas, Kallinich Tilmann, Mages Hans Werner, Bonhagen Kerstin, Radbruch Andreas, Hamelmann Eckard, Kroczek Richard A

Abstract excerpt

The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We examined ICOS(+) T cells in the secondary lymphoid organs of nonmanipulated mice, in the context of an "unbiased" immune system shaped by environmental antigens. Using single cell analysis, ICOS(low)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 12538658
DOI: 10.1084/jem.20020632
PMCID: PMC2193816

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.PMID 12538658Read ↗

Protective effector memory CD4 T cells depend on ICOS for survival.Semantic proximity Read ↗

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ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.Semantic proximity Read ↗

Inducible costimulator-ligand (ICOS-L).Semantic proximity Read ↗

Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligandSemantic proximity Read ↗

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiencySemantic proximity Read ↗

The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS InfectionSemantic proximity Read ↗

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T CellsSemantic proximity Read ↗

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodiesSemantic proximity Read ↗

Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.Semantic proximity Read ↗

ICOS gene polymorphisms in B-cell chronic lymphocytic leukemia in the Polish population.Semantic proximity Read ↗

IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1.Semantic proximity Read ↗

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