Article
A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility.
Molecular and cellular biology - 15 Feb 2016
Gyobu Sayuri, Miyata Haruhiko, Ikawa Masahito, Yamazaki Daiju, Takeshima Hiroshi, Suzuki Jun, Nagata Shigekazu
Abstract excerpt
Transmembrane protein 16E (TMEM16E) belongs to the TMEM16 family of proteins that have 10 transmembrane regions and appears to localize intracellularly. Although TMEM16E mutations cause bone fragility and muscular dystrophy in humans, its biochemical function is unknown. In the TMEM16 family, TMEM16A and -16B serve as Ca(2+)-dependent Cl(-) channels, while TMEM16C, -16D, -16F, -16G, and -16J support...
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