Article
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.
The Journal of biological chemistry - 29 May 2009
Rock Jason R, O'Neal Wanda K, Gabriel Sherif E, Randell Scott H, Harfe Brian D, Boucher Richard C, Grubb Barbara R
Abstract excerpt
For almost two decades, it has been postulated that calcium-activated Cl(-) channels (CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC. We have studied the airway bioelectrics of neonatal mice homozygous for a null allele of Tmem16a...
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