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Article

Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis.

International journal of molecular sciences - 24 May 2013

Watanabe Kenji, Shibuya Shuichi, Koyama Hirofumi, Ozawa Yusuke, Toda Toshihiko, Yokote Koutaro, Shimizu Takahiko

Abstract excerpt

Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O2·-). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenotypes in several types of mouse tissue, SOD1 is essential for the maintenance of tissue homeostasis. To clarify the...

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Identifiers

PMID: 23708100
DOI: 10.3390/ijms140610998
PMCID: PMC3709714

Genes

SOD1

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