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Article

Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice.

Redox biology - 1 Sept 2025

Geng Anke, Wang Xiaona, Wu Zhenkai, Liu Zhihao, Huang Xiao, Wang Xiyue, Sun Xiaoxiang, Wang Yingjie, Chen Jiayu, Jiang Ying, Tang Huanyin, Mao Zhiyong

Abstract excerpt

The free radical theory of aging suggests that oxidative stress from free radicals contributes to aging. While free radicals cause DNA damage and cellular dysfunction, they also regulate essential signaling pathways. This duality complicates direct testing of the theory in mice, as demonstrated by the minor lifespan impact of Sod1 knockout. We hypothesize that base excision repair mechanisms, that involve SIRT2,...

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Identifiers

PMID: 40690812
DOI: 10.1016/j.redox.2025.103770
PMCID: PMC12301975

Genes

SIRT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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