Article
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004
Jiang Dawei, Xiao Bailong, Yang Dongmei, Wang Ruiwu, Choi Philip, Zhang Lin, Cheng Heping, Chen S R Wayne
Abstract excerpt
The cardiac ryanodine receptor (RyR2) governs the release of Ca2+ from the sarcoplasmic reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to ventricular tachycardia (VT) and sudden death, but the precise molecular mechanism is unclear. It is known that when the sarcoplasmic reticulum store Ca2+ content reaches a critical level, spontaneous Ca2+ release occurs, a process we refer to...
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