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Article

The regulatory BCL2 promoter polymorphism (-938C>A) is associated with relapse and survival of patients with oropharyngeal squamous cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2009

Lehnerdt G F, Franz P, Bankfalvi A, Grehl S, Kelava A, Nückel H, Lang S, Schmid K W, Siffert W, Bachmann H S

Abstract excerpt

BACKGROUND: Expression of the antiapoptotic and antiproliferative protein B-cell lymphoma 2 (Bcl-2) has been repeatedly shown to be associated with better locoregional control and patients' survival in oropharyngeal squamous cell carcinoma (OSCC). A regulatory (-938C>A) single-nucleotide polymorphism (SNP) in the inhibitory P2 BCL2 gene promoter generates significantly different BCL2 promoter activities and has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, bcl-2

Share to Neoplasm Recurrence, Local

Share to Oropharyngeal Neoplasms

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-bcl-2

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Source

Identifiers

PMID: 19196738
DOI: 10.1093/annonc/mdn763

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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