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DPPA5 Supports Pluripotency and Reprogramming by Regulating NANOG Turnover

13 Dec 2015

Abstract excerpt

Although a specific group of transcription factors such as OCT4, SOX2, and NANOG are known to play essential roles in pluripotent stem cell (PSC) self-renewal, pluripotency, and reprogramming, other factors and the key signaling pathways regulating these important properties are not completely understood. Here, we demonstrate that the PSC marker Developmental Pluripotency Associated 5 (DPPA5) plays an important...

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PMID: 26661329
DOI: 10.1002/stem.2252

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