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Article

α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal

30 Jul 2015

Abstract excerpt

Substrate composition significantly impacts human pluripotent stem cell (hPSC) self-renewal and differentiation, but relatively little is known about the role of endogenously produced extracellular matrix (ECM) components in regulating hPSC fates. Here we identify α-5 laminin as a signature ECM component endogenously synthesized by undifferentiated hPSCs cultured on defined substrates. Inducible shRNA knockdown...

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PMID: 26235893
DOI: 10.1016/j.stemcr.2015.06.009

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