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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

2 Jan 2008

Abstract excerpt

The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans. The T cell populations that are available for adoptive immunotherapy include both effector memory and central memory cells, and these differ in phenotype, function, and homing. The efficacy of adoptive immunotherapy requires that transferred T cells persist in...

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PMID: 18060041
DOI: 10.1172/jci32103

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