Article
The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.
Disease models & mechanisms - 1 Mar 2016
Lee Soojin, Bang Se Min, Hong Yoon Ki, Lee Jang Ho, Jeong Haemin, Park Seung Hwan, Liu Quan Feng, Lee Im-Soon, Cho Kyoung Sang
Abstract excerpt
Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca(2+)-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious to neuronal health, its beneficial effects against AD neuropathology have also been reported, and the roles of DSCR1 on...
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