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Article

Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.

Scientific reports - 4 Nov 2015

Wang Xue, Perumalsamy Haribalan, Kwon Hyung Wook, Na Young-Eun, Ahn Young-Joon

Abstract excerpt

The human β-amyloid (Aβ) cleaving enzyme (BACE-1) is a target for Alzheimer's disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole Agastache rugosa plant had anti-BACE-1 and behavioral activities in Drosophila melanogaster AD models and to determine acacetin's mechanism of action. Acacetin (100, 300, and 500 μM) rescued amyloid precursor protein...

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Source

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Identifiers

PMID: 26530776
DOI: 10.1038/srep16127
PMCID: PMC4632086

Genes

APP
BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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