Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Neuroprotective Function of Apical-Basal Polarity Gene Crumbs in Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration

18 Nov 2013

Abstract excerpt

Alzheimer's disease (AD, OMIM: 104300), a progressive neurodegenerative disorder with no cure to date, is caused by the generation of amyloid-beta-42 (Aβ42) aggregates that trigger neuronal cell death by unknown mechanism(s). We have developed a transgenic Drosophila eye model where misexpression of human Aβ42 results in AD-like neuropathology in the neural retina. We have identified an apical-basal polarity gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Hippo pathway signaling and YAP/TAZ
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24260128
DOI: 10.1371/journal.pone.0078717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Neuroprotective Function of Apical-Basal Polarity Gene Crumbs in Amyloid Beta 42 (Aβ42) Mediated NeurodegenerationPMID 24260128Read ↗

Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s DiseaseSemantic proximity Read ↗

Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs.Semantic proximity Read ↗

The Drosophila Amyloid Precursor Protein homologue mediates neuronal survival and neuro-glial interactionsSemantic proximity Read ↗

pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicitySemantic proximity Read ↗

The Drosophila amyloid precursor protein homologue mediates neuronal survival and neuroglial interactionsSemantic proximity Read ↗

The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.Semantic proximity Read ↗

Diverse functions and pathogenetic role of Crumbs in retinopathy.Semantic proximity Read ↗

Changes in endolysosomal organization define a pre-degenerative state in the <i>crumbs</i> mutant <i>Drosophila</i> retinaSemantic proximity Read ↗

The physiological role of presenilins in cellular differentiation: lessons from model organisms.Semantic proximity Read ↗

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived NeuronsSemantic proximity Read ↗

Crumbs homologue 1 in polarity and blindness.Semantic proximity Read ↗

A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eyeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.