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Article

Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2011

Nakai Yasuhiro, Horiuchi Junjiro, Tsuda Manabu, Takeo Satomi, Akahori Shin, Matsuo Takashi, Kume Kazuhiko, Aigaki Toshiro

Abstract excerpt

Sleep is a fundamental biological process for all animals. However, the molecular mechanisms that regulate sleep are still poorly understood. Here we report that sleep-like behavior in Drosophila is severely impaired by mutations in sarah (sra), a member of the Regulator of Calcineurin (RCAN) family of genes. Sleep reduction in sra mutants is highly correlated with decreases in Sra protein levels. Pan-neural...

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Identifiers

PMID: 21900555
DOI: 10.1523/JNEUROSCI.1337-11.2011
PMCID: PMC6623415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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