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Article

Genetic analysis of Runx2 function during intramembranous ossification

1 Jan 2015

Abstract excerpt

Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation and its haploinsufficiency leads to cleidocranial dysplasia because of a defect in osteoblast differentiation during bone formation through intramembranous ossification. The cellular origin and essential period for Runx2 function during osteoblast differentiation in intramembranous ossification...

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PMID: 26657773
DOI: 10.1242/dev.128793

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