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Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast-Specific Expression

1 Apr 2014

Abstract excerpt

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. The expression of Runx2 is the first requisite step for the lineage determination from mesenchymal stem cells to osteoblasts. Although the transcript from Runx2 distal promoter is majorly expressed in osteoblasts, the promoter failed to direct green fluorescent protein (GFP) expression to osteoblasts. To find the regulatory region, we...

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PMID: 24692107
DOI: 10.1002/jbmr.2240

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