Article

A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)

2025-05-15

Abstract excerpt

SOX9 and RUNX2 are lineage defining transcription factors that drive differentiation of chondrocyte and osteoblast lineages respectively from osteochondral progenitors. In limb development, these progenitors are specified first by SOX9 expression required for mesenchymal stem cell (MSC) condensation prior to RUNX2 activation and osteochondral differentiation to chondrocyte and osteoblast lineages. Unlike limb deve...

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Literature Corpus work: 9022b7b6-3f02-579b-a6a1-76737d6697b9
DOI: 10.1101/2025.05.15.654100

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