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Article

Runx2: A master organizer of gene transcription in developing and maturing osteoblasts

1 Sept 2005

Abstract excerpt

Runx2 is essential for osteoblast development and proper bone formation. A member of the Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate transcription of numerous genes and thereby control osteoblast development from mesenchymal stem cells and maturation into osteocytes. Although necessary for gene transcription and osteoblast development, Runx2 is not sufficient for...

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PMID: 16187316
DOI: 10.1002/bdrc.20043

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