Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.

doi:10.1016/j.gene.2015.11.049

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Article

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis.

Gene - 15 Feb 2016

Kaur Simran J, McKeown Stephanie R, Rashid Shazia

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads to paralysis of the whole body. Most ALS cases are sporadic, though about 5-10% are familial. ALS is caused by multiple factors including mutation in any one of a number of specific genes, one of the most frequently affected is...

Topics

Amino Acid Sequence
Amyotrophic Lateral Sclerosis
Animals
Genetic Therapy
Humans
Molecular Sequence Data
Mutation
Reactive Oxygen Species
Superoxide Dismutase
Superoxide Dismutase-1

Source

Open in PubMed

Identifiers

PMID: 26657039
DOI: 10.1016/j.gene.2015.11.049

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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