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Article

Mitochondrial dysfunction and amyotrophic lateral sclerosis.

Muscle & nerve - 1 May 2006

Hervias Isabel, Beal M Flint, Manfredi Giovanni

Abstract excerpt

The causes of motor neuron death in amyotrophic lateral sclerosis (ALS) are still unknown. Several lines of evidence suggest that mitochondrial dysfunction may be involved in the pathogenesis of ALS. Biochemical and morphological mitochondrial abnormalities have been demonstrated in postmortem spinal cords of ALS patients. Furthermore, in transgenic mice expressing mutant Cu,Zn-superoxide dismutase (SOD1), the...

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Identifiers

PMID: 16372325
DOI: 10.1002/mus.20489

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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