Article
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
Molecular pathology : MP - 1 Dec 2001
Cluskey S, Ramsden D B
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most common variant of motor neurone disease affecting adults that usually strikes during mid to late life. Its aetiology is still poorly understood, although a major breakthrough came with the discovery that mutations in the Cu/Zn superoxide dismutase (SOD1) gene affect approximately 20% of patients with familial ALS. Experiments using both transgenic mice and ALS...
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