Article
SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.
Advances in biological regulation - 1 Jan 2016
Hayashi Yuki, Homma Kengo, Ichijo Hidenori
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disorder that is characterized by the selective death of motor neurons. While the fundamental cause of the disorder is still unclear, the first identified risk gene, Cu,Zn superoxide dismutase (SOD1), has led to the proposal of several mechanisms that are relevant to its pathogenesis. These include excitotoxicity, oxidative stress, ER stress,...
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