Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase.

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Article

Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase.

Pathologie-biologie - 1 Jan 1996

Gurney M E, Cutting F B, Zhai P, Andrus P K, Hall E D

Abstract excerpt

Oxidative mechanisms of damage have been implicated indirectly in the damage to brain tissue caused acutely by ischemia or chronically by neurodegenerative diseases. A direct link between pathogenesis and antioxidant enzyme systems has come from studies of a genetic form of amyotrophic lateral sc...

Topics

Amyotrophic Lateral Sclerosis
Animals
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 21
Excitatory Amino Acid Antagonists
Humans
Mice
Mice, Transgenic
Mutation
Riluzole
Superoxide Dismutase
Thiazoles
Vitamin E

Source

Open in PubMed

Identifiers

PMID: 8734301

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8734301-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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