Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.

Abstract excerpt

The mechanisms involved in selective motor neuron degeneration in amyotrophic lateral sclerosis remain unknown more than 135 years after the disease was first described. Although most cases have no known cause, mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) have been implicated in a fraction of familial cases of the disease. Transgenic mouse models with mutations in the SOD1 gene and other ALS...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axonal Transport
• Share to Axons
• Share to Caspases