Molecular genetic basis of familial ALS.

Abstract excerpt

Familial amytrophic lateral sclerosis (FALS) is transmitted in a mendelian fashion as an autosomal dominant (DFALS) or an autosomal recessive (RFALS) trait. Both DFALS and RFALS are genetically heterogeneous. Fifteen percent of DFALS families have mutations in the gene for Cu, Zn superoxide dismu...

Topics

• Amyotrophic Lateral Sclerosis
• Animals
• Humans
• Mice
• Mutation
• Superoxide Dismutase