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Article

Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila.

Journal of molecular cell biology - 1 Jun 2017

Tu Renjun, Qian Jinjun, Rui Menglong, Tao Nana, Sun Mingkuan, Zhuang Yan, Lv Huihui, Han Junhai, Li Moyi, Xie Wei

Abstract excerpt

Neuroligins (Nlgs) are transmembrane cell adhesion molecules playing essential roles in synapse development and function. Genetic mutations in neuroligin genes have been linked with some neurodevelopmental disorders such as autism. These mutated Nlgs are mostly retained in the endoplasmic reticulum (ER). However, the mechanisms underlying normal Nlg maturation and trafficking have remained largely unknown. Here,...

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Identifiers

PMID: 28498949
DOI: 10.1093/jmcb/mjx015
PMCID: PMC5907836

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