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Article

The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity.

The Journal of cell biology - 7 Dec 2015

Vichas Athea, Laurie Matthew T, Zallen Jennifer A

Abstract excerpt

Alternative splicing can have profound consequences for protein activity, but the functions of most alternative splicing regulators are not known. We show that Obelus, a conserved Ski2-family helicase, is required for cell polarity and adherens junction organization in the Drosophila melanogaster embryo. In obelus mutants, epithelial cells display an expanded apical domain, aggregation of adherens junctions at...

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Identifiers

PMID: 26644515
DOI: 10.1083/jcb.201504083
PMCID: PMC4674277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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