Article
The minor spliceosome component U4atac regulates JAK/STAT signaling to modulate hematopoiesis and immune responses in Drosophila melanogaster.
Nature communications - 16 Jul 2026
Shikara Dania, Bishop Eden, Barton Nathan, Makdissi Stephanie, Kailasam Senthilkumar, György Attila, Siekhaus Daria E, Borroto Maria Carla, Campeau Philippe M, Vong Linda, Roifman Chaim M, Parsons Brendon D, Di Cara Francesca
Abstract excerpt
The small nuclear RNA U4atac is a core component of the minor spliceosome. In humans, homozygous or compound heterozygous point mutations in U4atac cause rare developmental disorders, such as Roifman syndrome, characterized by growth restriction, brain anomalies, and immune deficiency. To better define the pathophysiological role of U4atac mutations, we here establish a model of minor spliceosome dysfunction by...
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- Animals
- Drosophila melanogaster
- Hematopoiesis
- Drosophila Proteins
- Signal Transduction