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Article

α-synuclein interacts with SOD1 and promotes its oligomerization.

Molecular neurodegeneration - 8 Dec 2015

Helferich Anika M, Ruf Wolfgang P, Grozdanov Veselin, Freischmidt Axel, Feiler Marisa S, Zondler Lisa, Ludolph Albert C, McLean Pamela J, Weishaupt Jochen H, Danzer Karin M

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are both neurodegenerative diseases leading to impaired execution of movement. α-Synuclein plays a central role in the pathogenesis of PD whereas Cu, Zn superoxide dismutase (SOD1) is a key player in a subset of familial ALS cases. Under pathological conditions both α-synuclein and SOD1 form oligomers and fibrils. In this study we...

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Source

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Identifiers

PMID: 26643113
DOI: 10.1186/s13024-015-0062-3
PMCID: PMC4672499

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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