Article
Abundant contribution of short tandem repeats to gene expression variation in humans.
Nature genetics - 1 Jan 2016
Gymrek Melissa, Willems Thomas, Guilmatre Audrey, Zeng Haoyang, Markus Barak, Georgiev Stoyan, Daly Mark J, Price Alkes L, Pritchard Jonathan K, Sharp Andrew J, Erlich Yaniv
Abstract excerpt
The contribution of repetitive elements to quantitative human traits is largely unknown. Here we report a genome-wide survey of the contribution of short tandem repeats (STRs), which constitute one of the most polymorphic and abundant repeat classes, to gene expression in humans. Our survey identified 2,060 significant expression STRs (eSTRs). These eSTRs were replicable in orthogonal populations and expression...
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