Article
STaRRRT: a table of short tandem repeats in regulatory regions of the human genome.
BMC genomics - 15 Nov 2013
Bolton Katherine A, Ross Jason P, Grice Desma M, Bowden Nikola A, Holliday Elizabeth G, Avery-Kiejda Kelly A, Scott Rodney J
Abstract excerpt
BACKGROUND: Tandem repeats (TRs) are unstable regions commonly found within genomes that have consequences for evolution and disease. In humans, polymorphic TRs are known to cause neurodegenerative and neuromuscular disorders as well as being associated with complex diseases such as diabetes and cancer. If present in upstream regulatory regions, TRs can modify chromatin structure and affect transcription;...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
