Article
The impact of short tandem repeat variation on gene expression.
Nature genetics - 1 Nov 2019
Fotsing Stephanie Feupe, Margoliash Jonathan, Wang Catherine, Saini Shubham, Yanicky Richard, Shleizer-Burko Sharona, Goren Alon, Gymrek Melissa
Abstract excerpt
Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans. However, genome-wide studies of the effects of STRs on gene expression thus far have had limited power to detect associations and provide insights into putative mechanisms. Here, we leverage whole-genome sequencing and expression data for 17 tissues from the Genotype-Tissue Expression Project to identify more than 28,000...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.