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Article

Characterization of genome-wide STR variation in 6487 human genomes.

Nature communications - 12 Apr 2023

Shi Yirong, Niu Yiwei, Zhang Peng, Luo Huaxia, Liu Shuai, Zhang Sijia, Wang Jiajia, Li Yanyan, Liu Xinyue, Song Tingrui, Xu Tao, He Shunmin

Abstract excerpt

Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome. Many STR loci have been associated with a range of human genetic disorders. However, most population-scale studies on STR variation in humans have focused on European ancestry cohorts or are limited by sequencing depth. Here, we depicted a comprehensive map of 366,013 polymorphic STRs (pSTRs) constructed from 6487 deeply sequenced...

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Identifiers

PMID: 37045857
DOI: 10.1038/s41467-023-37690-8
PMCID: PMC10097659

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