Article

Genomic properties of structural variants and short tandem repeats that impact gene expression and complex traits in humans

2019-07-25

Abstract excerpt

Structural variants (SVs) and short tandem repeats (STRs) comprise a broad group of diverse DNA variants which vastly differ in their sizes and distributions across the genome. Here, we show that different SV classes and STRs differentially impact gene expression and complex traits. Functional differences between SV classes and STRs include their genomic locations relative to eGenes, likelihood of being associated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecd5abed-0ebc-5791-8e45-c3b7617f1d50
DOI: 10.1101/714477

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic properties of structural variants and short tandem repeats that impact gene expression and complex traits in humansDOI 10.1101/714477Read

Properties of structural variants and short tandem repeats associated with gene expression and complex traits.Semantic proximity Read

Abundant contribution of short tandem repeats to gene expression variation in humansSemantic proximity Read

Multi-tissue analysis reveals short tandem repeats as ubiquitous regulators of gene expression and complex traitsSemantic proximity Read

Abundant contribution of short tandem repeats to gene expression variation in humans.Semantic proximity Read

Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genesSemantic proximity Read

The impact of short tandem repeat variation on gene expression.Semantic proximity Read

An integrated map of structural variation in 2,504 human genomes.Semantic proximity Read

Characterization of genome-wide STR variation in 6487 human genomes.Semantic proximity Read

Population-scale variability at short tandem repeat loci reveals pathogenicity signatureSemantic proximity Read

Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy vs. Precision.Semantic proximity Read

WebSTR: A Population-wide Database of Short Tandem Repeat Variation in Humans.Semantic proximity Read

Sequencing and characterizing short tandem repeats in the human genome.Semantic proximity Read