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Article

'Deadman' and 'Passcode' microbial kill switches for bacterial containment.

Nature chemical biology - 1 Feb 2016

Chan Clement T Y, Lee Jeong Wook, Cameron D Ewen, Bashor Caleb J, Collins James J

Abstract excerpt

Biocontainment systems that couple environmental sensing with circuit-based control of cell viability could be used to prevent escape of genetically modified microbes into the environment. Here we present two engineered safeguard systems known as the 'Deadman' and 'Passcode' kill switches. The Deadman kill switch uses unbalanced reciprocal transcriptional repression to couple a specific input signal with cell...

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Identifiers

PMID: 26641934
DOI: 10.1038/nchembio.1979
PMCID: PMC4718764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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