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Article

Programmable cells: interfacing natural and engineered gene networks.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004

Kobayashi Hideki, Kaern Mads, Araki Michihiro, Chung Kristy, Gardner Timothy S, Cantor Charles R, Collins James J

Abstract excerpt

Novel cellular behaviors and characteristics can be obtained by coupling engineered gene networks to the cell's natural regulatory circuitry through appropriately designed input and output interfaces. Here, we demonstrate how an engineered genetic circuit can be used to construct cells that respond to biological signals in a predetermined and programmable fashion. We employ a modular design strategy to create...

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Identifiers

PMID: 15159530
DOI: 10.1073/pnas.0402940101
PMCID: PMC420408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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