Article
Library of synthetic transcriptional AND gates built with split T7 RNA polymerase mutants.
Proceedings of the National Academy of Sciences of the United States of America - 26 Mar 2013
Shis David L, Bennett Matthew R
Abstract excerpt
The construction of synthetic gene circuits relies on our ability to engineer regulatory architectures that are orthogonal to the host's native regulatory pathways. However, as synthetic gene circuits become larger and more complicated, we are limited by the small number of parts, especially transcription factors, that work well in the context of the circuit. The current repertoire of transcription factors...
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