Article
RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2012
Stacey David, Bilbao Ainhoa, Maroteaux Matthieu, Jia Tianye, Easton Alanna C, Longueville Sophie, Nymberg Charlotte, Banaschewski Tobias, Barker Gareth J, Büchel Christian, Carvalho Fabiana, Conrod Patricia J, Desrivières Sylvane, Fauth-Bühler Mira, Fernandez-Medarde Alberto, Flor Herta, Gallinat Jürgen, Garavan Hugh, Bokde Arun L W, Heinz Andreas, Ittermann Bernd, Lathrop Mark, Lawrence Claire, Loth Eva, Lourdusamy Anbarasu, Mann Karl F, Martinot Jean-Luc, Nees Frauke, Palkovits Miklós, Paus Tomas, Pausova Zdenka, Rietschel Marcella, Ruggeri Barbara, Santos Eugenio, Smolka Michael N, Staehlin Oliver, Jarvelin Marjo-Riitta, Elliott Paul, Sommer Wolfgang H, Mameli Manuel, Müller Christian P, Spanagel Rainer, Girault Jean-Antoine, Schumann Gunter
Abstract excerpt
The firing of mesolimbic dopamine neurons is important for drug-induced reinforcement, although underlying genetic factors remain poorly understood. In a recent genome-wide association metaanalysis of alcohol intake, we identified a suggestive association of SNP rs26907 in the ras-specific guanin...
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