Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

doi:10.1084/jem.20110921

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Article

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

The Journal of experimental medicine - 4 Jul 2011

Fabbri Giulia, Rasi Silvia, Rossi Davide, Trifonov Vladimir, Khiabanian Hossein, Ma Jing, Grunn Adina, Fangazio Marco, Capello Daniela, Monti Sara, Cresta Stefania, Gargiulo Ernesto, Forconi Francesco, Guarini Anna, Arcaini Luca, Paulli Marco, Laurenti Luca, Larocca Luigi M, Marasca Roberto, Gattei Valter, Oscier David, Bertoni Francesco, Mullighan Charles G, Foá Robin, Pasqualucci Laura, Rabadan Raul, Dalla-Favera Riccardo, Gaidano Gianluca

Abstract excerpt

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains <20...

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Identifiers

PMID: 21670202
DOI: 10.1084/jem.20110921
PMCID: PMC3135373

Genes

NOTCH1

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