Article
Genetic evolution in chronic lymphocytic leukaemia.
Best practice & research. Clinical haematology - 1 Mar 2016
Delgado Julio, Villamor Neus, López-Guillermo Armando, Campo Elías
Abstract excerpt
Next-generation sequencing provides a comprehensive understanding of the genomic, epigenomic and transcriptomic underpinnings of chronic lymphocytic leukaemia. Recent studies have uncovered new drivers, including mutations in non-coding regions, and signalling pathways whose role in cancer was previously unknown or poorly understood. Moreover, massive scale epigenomics and transcriptomics have supplied the...
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