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Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

14 Dec 2018

Abstract excerpt

Metastasis to distant organs is a major cause for solid cancer mortality, and the acquisition of migratory and invasive phenotype is a key factor in initiation of malignancy. In this study we investigated the contribution of Mixed-Lineage Kinase 4 (MLK4) to aggressive phenotype of breast cancer cells. Our TCGA cancer genomic data analysis revealed that amplification or mRNA upregulation of MLK4 occurred in 23% of...

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PMID: 30552384
DOI: 10.1038/s41388-018-0618-0

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