Article
Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System.
The Journal of biological chemistry - 29 Jan 2016
Hashimoto Misuzu, Murata Kazuya, Ishida Junji, Kanou Akihiko, Kasuya Yoshitoshi, Fukamizu Akiyoshi
Abstract excerpt
Protein arginine methyltransferase 1 (PRMT1) is involved in cell proliferation, DNA damage response, and transcriptional regulation. Although PRMT1 is extensively expressed in the CNS at embryonic and perinatal stages, the physiological role of PRMT1 has been poorly understood. Here, to investigate the primary function of PRMT1 in the CNS, we generated CNS-specific PRMT1 knock-out mice by the Cre-loxP system....
Topics
- Animals
- Brain
- Cell Lineage
- Cell Proliferation
- Central Nervous System
- DNA Damage
- Gene Deletion
- Genotype
- Glycoproteins
- Mice
- Mice, Knockout
- Mutation
- Myelin Basic Protein
- Myelin Sheath