Article
ZFP191 is required by oligodendrocytes for CNS myelination.
Genes & development - 1 Feb 2010
Howng Shen Yi B, Avila Robin L, Emery Ben, Traka Maria, Lin Wensheng, Watkins Trent, Cook Susan, Bronson Roderick, Davisson Muriel, Barres Ben A, Popko Brian
Abstract excerpt
The controlling factors that prompt mature oligodendrocytes to myelinate axons are largely undetermined. In this study, we used a forward genetics approach to identify a mutant mouse strain characterized by the absence of CNS myelin despite the presence of abundant numbers of late-stage, process-extending oligodendrocytes. Through linkage mapping and complementation testing, we identified the mutation as a single...
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