Article

Defective myelination in an RNA polymerase III mutant leukodystrophic mouse

2020-12-10

Abstract excerpt

RNA polymerase (Pol) III synthesizes abundant short non-coding RNAs that have essential functions in protein synthesis, secretion and other processes. Despite the ubiquitous functions of these RNAs, mutations in Pol III subunits cause Pol III-related leukodystrophy, an early-onset neurodegenerative disease. The basis of this neural sensitivity and the mechanisms of disease pathogenesis are unknown. Here we show th...

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Literature Corpus work: 582b3330-6677-59ed-87cf-cb77ab353e06
DOI: 10.1101/2020.12.09.418657

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