Article
The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.
Blood - 11 Aug 2011
Elstak Edo D, Neeft Maaike, Nehme Nadine T, Voortman Jarno, Cheung Marc, Goodarzifard Monireh, Gerritsen Hans C, van Bergen En Henegouwen Paul M P, Callebaut Isabelle, de Saint Basile Geneviève, van der Sluijs Peter
Abstract excerpt
Cytotoxic T lymphocytes (CTLs) kill target cells through the polarized release of lytic molecules from secretory lysosomes. Loss of munc13-4 function inhibits this process and causes familial hemophagocytic lymphohistiocytosis type 3 (FHL3). munc13-4 binds rab27a, but the necessity of the complex remains enigmatic, because studies in knockout models suggest separate functions. In the present study, we describe a...
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