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Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges

2 Dec 2015

Abstract excerpt

Embryonic stem cells (ESCs) are chiefly characterized by their ability to self-renew and to differentiate into any cell type derived from the three main germ layers. It was demonstrated that somatic cells could be reprogrammed to form induced pluripotent stem cells (iPSCs) via various strategies. Gene editing is a technique that can be used to make targeted changes in the genome, and the efficiency of this...

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PMID: 26633382
DOI: 10.3390/ijms161226119

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