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Article

Improving the affinity of antigens for mutated antibodies by use of statistical molecular design.

Journal of peptide science : an official publication of the European Peptide Society - 1 Jul 2008

Mandrika Ilona, Prusis Peteris, Bergström Jakob, Yahorava Sviatlana, Wikberg Jarl E S

Abstract excerpt

We demonstrate the use of statistical molecular design (SMD) in the selection of peptide libraries aimed to systematically investigate antigen-antibody binding spaces. Earlier, we derived two novel antibodies by mutating the complementarity-determining region of the anti-p24 (HIV-1) single chain Fv antibody, CB4-1 that had lost their affinity for a p24 epitope-homologous peptide by 8- and 60-fold. The present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18200617
DOI: 10.1002/psc.999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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